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Project

Study of crosstalk between beta2-adrenergic signals and the NF-κB cascade. Relevance for neuroinflammation/ neurodegeneration.

Recent studies indicate signals derived from the beta2 adrenergic receptor (adrb2) modulate inflammation. In this study we use different in vitro and in vivo models of neuroinflammation to unravel the molecular basis of this interaction. More specifically, we want to address how beta-adrenergic signals modulate the molecular function of NF-κB, one of the crucial mediators of inflammatory reactions.

Date:1 Oct 2007 →  30 Sep 2013
Keywords:adrb2, signal transduction, (neuro-)inflammation, NF-κB
Disciplines:Other biotechnology, bio-engineering and biosystem engineering, Other (bio)medical engineering, Systems biology, Medical biochemistry and metabolism, Biomaterials engineering, Biological system engineering, Biochemistry and metabolism, Biomechanical engineering, Industrial biotechnology, Environmental engineering and biotechnology