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Project
Study of the aging process: the role of N-glycosylation, hormones and the Klotho gene.
N-glycosylation is altered during aging and specific glyco-genes are responsible for this process. We will analyze the regulation of involved glyco-genes by in silico analysis and functional promoter studies. Next, we will study the influence of alterations of the N-glycosylation pattern on the aging process itself as well as on aging-related signaling pathways. This will be done both in vitro and in vivo.
Date:1 Oct 2010 → 30 Sep 2013
Keywords:aging, N-glycosylation, mice
Disciplines:Biological system engineering, Other (bio)medical engineering, Other biotechnology, bio-engineering and biosystem engineering, Biomaterials engineering, Industrial biotechnology, Gerontology and geriatrics, Systems biology, Biomechanical engineering, Nursing, Environmental engineering and biotechnology