Single-cell and spatial multi-omics for biomedicine

Cells are the biological unit of life. As a consequence, molecular techniques to investigate single cells comprehensively are pivotal for developing mechanistic understanding of the development, function and aging of human organs, the etiopathogenesis of diseases and devising the next generation of precision medicine. This IOF programme will valorize our research in this area, including engineering of single-cell and spatial multi-omics analysis technologies, and their application to unravel human cell biology in health and disease. The valorisation strategies include increasing external funding, patents claiming novel methods to biomarkers and druggable targets for specific disorders, service provision and collaboration with external academia and industry, as well as training and consultancy in this complex interdisciplinary field. Finally, we envision spin-off creation for multi-omic biomarker and druggable target discovery.

Keywords:spatial multi-omics, single-cell multi-omics, microfluidics, higher order biomarkers, human cell atlas in health and disease

Disciplines:Single-cell data analysis, Computational transcriptomics and epigenomics, Data visualisation and high-throughput image analysis, Cancer biology, Molecular diagnostics