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Project

Role of ZEB2 in T-cell acute lymphoblastic leukemia (T-ALL) initiation and Progression

High ZEB2 levels were seen in ETP-ALL and preliminary data from our novel conditional overexpression mouse model suggests a key role for this transcription factor in T-ALL. Here we will investigate whether Zeb2 is altering the formation/function of leukemic cancer stem cells in this aggressive subtype of T-ALL.

Date:1 Jan 2013 →  31 Dec 2015
Keywords:leukemia, mouse model, stem cells
Disciplines:Systems biology, Oncology, Laboratory medicine, Hematology, Morphological sciences