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Project

Role of protein crystals in asthma

Since 1853 it is known that Charcot Leyden crystals are found in asthmatic airways, and here we propose they promote allergy. We combine immunology with structural biology to investigate the structure, function and evolutionary origins of these and related protein crystals. Through novel tool creation and multidisciplinary research, we envisage the unmasking of a novel drugable pathway in asthma.

Date:1 Jan 2017 →  31 Oct 2022
Keywords:eosinophils, epithelial cells, asthma
Disciplines:Medical biochemistry and metabolism, Immunology, Plant biology, Respiratory medicine, Molecular and cell biology, Biophysics, Condensed matter physics and nanophysics, Biochemistry and metabolism, Systems biology, Medicinal and biomolecular chemistry