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Role of intestinal barrier dysfunction for the pathogenesis of spondyloarthritis (01D01718)

Patients with spondyloarthritis (SpA), a chronic inflammatory rheumatic disease, usually present with an altered composition of intestinal microbiota (dysbiosis). We want to investigate how dysbiosis influences gut epithelial integrity and the subepithelial immune system. Furthermore we will correlate the local effects of dysbiosis with biomarker profiles, acting as surrogate indicators of gut inflammation and bacterial translocation.

Date:1 Oct 2018  →  Today
Keywords:spondyloarthritis, mucosal barrier, bacterial dysbiosis, gut inflammation
Disciplines:Palliative care and end-of-life care, Orthopaedics, Regenerative medicine, Other health sciences, Laboratory medicine, Other clinical sciences, Other translational sciences, Other basic sciences, Immunology, Other medical and health sciences, Other paramedical sciences, Nursing