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Role of cell adhesion-mediated signaling in craniofacial malformations: an integrated molecular and morphological study (01G01908w)

The research consortium analyzes how classical cadherins and delta-protocadherins, as well as their associated intracellular signaling pathways, are involved in correct development of complex craniofacial structures. Xenopus models will be used to screen for the most relevant molecules; those will be analyzed functionally in both Xenopus and zebrafish; the most interesting molecules will eventually be analyzed in mouse models.

Date:1 Jan 2008  →  31 Oct 2013
Keywords:animal models, craniofacial defects, cell-cell adhesion
Disciplines:Veterinary medicine, Genetics, Animal biology