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Project

The role of capsular exopolysaccharide depolymerases as host determinant for Klebsiella pneumoniae phages, and their enzymatic properties.

This doctoral research proposal investigates the unique relationship between the bacterial capsular serotype, bacteriophage-encoded depolymerases that degrade capsular exopolysaccharides and the bacteriophage host spectrum, specifically for Klebsiella pneumoniae bacteriophages. The enzymatic properties of these exopolysaccharide depolymerases will be analysed. A first-in-class phage engineering method will be introduced to study the role of these enzymes in the tail fibers of bacteriophages

Date:1 Oct 2016 →  30 Sep 2020
Keywords:Bacteriophages, enzymes, exopolysaccharide depolymerases
Disciplines:Infectious diseases, Bacteriology, Medical molecular engineering of nucleic acids and proteins