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Project
Research into the role and mechanism of caspase-7 in immunomodulation and in immunopathologies
Recent experimental data within our unit suggests a differential role for caspase-3 and -7. Conditional caspase-7 deficient mice were generated to be able to further investigate these findings. These mice will be used in certain murine experimental pathology models (EAE, I/R) and derived cells will be used for ex-vivo experiments to clarify the non-redundant role of caspase-7.
Date:1 Oct 2008 → 30 Sep 2012
Keywords:inflammation, mouse model, caspase-7
Disciplines:Industrial biotechnology, Other (bio)medical engineering, Biomaterials engineering, Other biotechnology, bio-engineering and biosystem engineering, Biological system engineering, Environmental engineering and biotechnology, Biomechanical engineering