Relation between residual beta cell function and glycemic variability in (pre)type 1 diabetes.

The established clinical network and the developed dynamic function tests and biological markers provide us with the unique opportunity to identify sufficiently large groups of high-risk first-degree relatives (> 50% risk of diabetes) of a proband with type 1 diabetes and of recent-onset type 1 diabetic patients with the overall aim to investigate the correlation between functional beta cell mass and glycemic variability in relation to metabolic outcome in order to determine thresholds of residual function below which:- glucose tolerance starts to decline sharply in relatives - the risk of deteriorating metabolic control and (severe) hypoglycemic events strongly increases in patients

Keywords:DIABETES

Disciplines:Endocrinology and metabolic diseases, Laboratory medicine

Project type:Collaboration project