Platelet fragmentation and the formation of platelet-derived extracellular vesicles

Circulating extracellular vesicles (EV) are derived from various cell types, of which the majority is derived from platelets. The biological cargo of platelet-derived EV includes a variety of biological molecules, such as surface receptors, coagulation proteins and cytokines. There is increased evidence that EV play an important role in regulating thrombotic and hemostatic processes, for example through mediating intercellular communication by releasing their cargo into distal recipient cells. However, the knowledge on the release and function of EV is limited and requires further investigation. With this project, we aim to increase the knowledge on the mechanisms involved in EV release as well as the pathophysiological role of EV in thrombotic disorders.

Keywords:Thrombus resolution, Fibrinolysis, Platelets, Microvesicles, Extracellular vesicles

Disciplines:Pathophysiology, Clinical hematology, Cytology