Physiologically based pharmacokinetic models for the accumulation of microcontaminants and immunological effects in harbour seals (Phoca vitulina) and harbour porpoises (Phocoena phocoena).

Aims:Development of a physiologically based pharmacokinetic model for long-term uptake and accumulation of microcontaminants by seals.Model evaluation by comparison of predicted values with observed results of microcontaminants in blood and biopsy (living animals) and other tissues (dead animals).Determination of the condition of seals by use of general condition-indices and more specific indications for homeostasis and stress by analysis of bloodsamples with special attention for endocrine effects and immunity.Making connections between exposure, accumulation and effects. By comparison with results from analysis of animals from different areas and by use of multivariate statistical methods we will check whether it is possible to find the cause of the effects.

Keywords:MICROCONTAMINANTS, SEALS

Disciplines:Sustainable chemistry, Animal biology, General biology, Aquatic sciences, challenges and pollution, Environmental science and management, Veterinary medicine

Project type:Collaboration project