Perform a systematic review of the published literature and unpublished data from ongoing clinical trial on diagnostic accuracy on commercially available hybridization-based technology for pyrazinamide resistance detection.

The goal of the systematic literature review and meta-analysis is to estimate the diagnostic accuracy of the PZA LPA assay for detection of PZA resistance in cultured MTB isolates and sputum samples from patients diagnosed with pulmonary TB with or without rifampicin resistance using three different reference standards: phenotypic DST (pDST), genotypic DST (gDST) and a composite reference standard (CRS). The goal is to, if the data allows, to estimate the diagnostic accuracy of the PZA LPA overall and stratified by sputum smear microscopy status, rifampicin resistance status and treatment outcome.

Keywords:TUBERCULOSIS

Disciplines:Clinical genetics and molecular diagnostics