Optimization of the synthesis of diarylphosphonate inhibitors of serin proteases using reaction calorimetry.

The synthesis of diaryl phosphonates, inhibitors of serine proteases, will be optimized and scaled up using reaction calorimetry. The reaction variables that allow for a more efficient Birum-Oleksyszyn reaction, will be identified and studied. In addition, general applicability of results will be assessed during the preparation of a library of potential serine protease inhibitors using a broader spectrum of synthetic substrates.

Keywords:UROKINASE, PROCESS OPTIMIZATION, CALORIMETRY

Disciplines:Organic chemistry, Chemical product design and formulation, Biomaterials engineering

Project type:Collaboration project