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Optimalisation of in vitro culture conditions (FTOC and OP9) of T cells from human hematopoietic stem cells for the generation and study of mature T cells

In this project we will further study and optimise the generation of mature CD3+TCRab+ (CD4+ and CD8+) T-cells from human HSC (from postnatal thymus and cord blood) using the in vitro OP9-DL1 culture system. Several methods for the generation of tumor antigen specific T-cells will be tested out. Finally, these tumor antigen specific T-cells will be introduced in a preclinical mouse model.

Date:1 Jan 2008 →  31 Dec 2010
Keywords:tumor antigen, immunotherapy, T cell
Disciplines:Other clinical sciences, Laboratory medicine, Other medical and health sciences, Regenerative medicine, Nursing, Palliative care and end-of-life care, Immunology, Other health sciences, Other translational sciences, Other basic sciences, Other paramedical sciences