Nickel-catalyzed imidoylative cross-coupling reactions.

During the research stay at UAntwerpen, nickel-catalyzed imidolyative cross-coupling reactions starting from readily available alkane- and arenecarboximidamides (amidine) substrates will be developed. This will deliver new synthetic methods to prepare important functionalized heterocycles, e.g. 5-aminopyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones, 4-imino-4H-imidazol-5-amines and 1,3,5- triazin-2-amines. Besides base metal catalysis, the use of synthetic strategies such as C-H functionalization and multicomponent reactions allow to obtain efficient synthetic methods in accordance with the principles of green chemistry.

Keywords:CROSS-COUPLING REACTIONS, ISOCYANIDE

Disciplines:Inorganic chemistry, Organic chemistry, Theoretical and computational chemistry, Other chemical sciences

Project type:Collaboration project