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Project

Next generation pharmacokinetic-pharmacodynamic modeling: dosage regimen for both curative and metaphylactic antimicrobial treatment taking antimicrobial resistance development into account

Current dosage regimens of antimicrobials have been determined for curative treatment without taking antimicrobial resistance into account. In this research proposal, optimal dosage regimen will be established for both curative and metaphylactic enrofloxacin treatment against avian pathogenic Escherichia coli in broilers. The effect of these dosage regimen on resistance development in both the target pathogen and the commensal gut microbiota will be evaluated.

Date:1 Jan 2017 →  31 Oct 2021
Keywords:antimicrobials, curative treatment, broiler chicken
Disciplines:Animal biology, Biomarker discovery and evaluation, Pharmacognosy and phytochemistry, Other pharmaceutical sciences, Veterinary medicine, Pharmacology, Medicinal products, Other agricultural, veterinary and food sciences, Toxicology and toxinology, Pharmaceutics, Other veterinary sciences, Drug discovery and development, Pharmacotherapy