New chemical reactivities in photoredox catalysis with CO2 and boronic acids as sustainable building blocks in batch and continuous-flow
Despite the changing face of chemistry, the necessity to produce molecules in a controlled manner has not diminished. However, the increasingly complex synthetic problems being posed by nature, medicine and materials demand new reactivity concepts and strategies in order to meet these challenges. Therefore, the development of new and benign methodologies facilitating the atom economical construction of biologically and industrially important molecules is an important pursuit from the viewpoint of Sustainable Chemistry. In this context, photoredox catalysis has come up as a strong contender for designing environmentally benign protocols for biologically relevant molecules. Nevertheless, scaling up the photochemical reaction with ease still poses a big challenge. Flow chemistry, being the one obvious solution for this, still needs more digging as well optimized protocols specifically focused in this direction. This project primarily deals with some challenging transformations with respect to photoredox chemistry, which is significant from the sustainable development point of view. Questions which will be explored include some real-world issues viz. scarcely reported CO2 fixations into small molecules via single electron reduction, boronic acid (derivatives) as a source of alkyl free radicals and last but not the least, the application of the developed methodologies towards the synthesis of pharmaceuticals/intermediates and natural products under photo-flow conditions.