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Project

Neuroendocine modulation of healthy aging.

Despite an increasing interest in, and knowledge of the fundamental, molecular processes that modulate ageing, many questions remain unanswered at this point. Although it is generally accepted that (neuro)endocrine factors are of prime importance to aging and possibly more specifically to healthy aging it still remains an open question what their identities are, and how they influence this process.Here, we propose two parallel approaches using high-throughput mass spectrometry, RNA interference and genetic engineering at the cellular level, all combined with functional tests to elucidate (some of) these neuroendocrine regulators of longevity in the model system Caenorhabditis elegans, and further study the molecular mechanism by which these affect healthy aging.
Date:1 Oct 2015 →  30 Sep 2019
Keywords:C. elegans, aging, neurobiology, neuropeptides
Disciplines:Animal biology, General biology