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Project

Molecular imaging and molecular profiling for head and neck, lung and rectal cancer MRT: application in dose-painting and response prediction.

The KUL-UCL-UG consortium has been contributing since 2003 (thanks to the support of the Foundation against Cancer) to validate the use of molecular imaging in Target Volume (TV) delineation for the treatment of head and neck (H1N), and rectal cancers. In line with the previous research projects, the general aim of the study proposal is: 1) to validate the dose-painting approach to escalate radiation dose on TV(s) delineated on PET images using tracers of metabolism, hypoxia and proliferation. In H&N tumores, a randomized phase II will be launched with loco-regional control as the primary endpoint; in lung tumors (NSCLC), a phase II study will be launched; 2) to validate the use of molecular imaging with PET and DW-MRI for response prediction early on during the course of concomitant chemo-radiotherapy. Response will be assessed on the surgical specimen for rectal cancer (pre-op chemo-radiation), or on imaging during the follow-up for H&N cancer and NSCLC; 3) to test the convergence of molecular imaging and molecular profiling for prediction of tumor response in patients with H&N, rectal and NSCL cancers.
Date:1 Jan 2011 →  31 Dec 2013
Keywords:Rectal tumours, Head and neck tumours, Lung tumours, Respons prediction, Imaging, Radiotherapy
Disciplines:Other biological sciences, Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences