Modulation of wound healing after glaucoma surgery.

Filtration surgery (trabeculectomy) is the most effective therapy to reduce an increased eye pressure in glaucoma patients over a long period. But in 30-50% of the cases, the surgery fails due to excessive wound healing. The process of wound healing is characterized by different stages: clot formation, inflammation, angiogenesis, and finally scar formation. This project has as an objective to inhibit wound healing by reducing every stage. Therefore, we will investigate the angiostatic, anti-inflammatory and the anti-fibrotic effect of microplasmin, different VEGF-inhibitors and steroids. This project will shed new light on fibrosis and scar formation after glaucoma surgery, a major problem area in glaucoma. This project may have clinical relevance on the visual prognosis of glaucoma patients.

Keywords:Wound healing, Glaucoma surgery

Disciplines:Ophthalmology and optometry