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Microwave a la carte flow chemistry (MIRACLE)
Microwaves are increasingly being used to intensify organic synthesis reactions and improve their outcome in terms of product purity. However, these improvements were mostly demonstrated on the scale of mL's using commercial equipment that relies on 2.45 GHz irradiation. Even though the advantages of microwave-based heating have been clearly demonstrated, we believe that this is merely the tip of the iceberg, and further significant improvements can be achieved by 1) moving to flow based systems, 2) using optimized signal waveforms (power and frequency) for a given reaction, 3) using reactors that provide multi-dimensional temperature control within the same heating chip. By truly exploring the entire design space available for advanced microwave-based thermal control systems on the microscale, we aim to enable a new scalable generation of flow devices that can generate with the high throughput in a fast and energy efficient manner large chemical compounds libraries.
Date:1 Oct 2020 → Today
Keywords:microwave engineering, microfluidics, flow chemistry, organic synthesis, computational electromagnetics
Disciplines:Microwave and millimeter wave technology, Electromagnetism and antenna technology, Microfluidics/flow chemistry, Organic chemical synthesis, Modelling not elsewhere classified