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Project
Metabolic engineering for the creation of a platform organism with an increased nucleotide sugar pool
The goal of this research is to create a platform organism with an increased intracellular pool of UDP-sugars. The developed technology is based on the principles of metabolic engineering of the model organism Escherichia coli. The created mutants will function as glycosylation platforms for the production of various oligosaccharides and glycoconjugates.
Date:1 Oct 2010 → 5 Jan 2016
Keywords:UDP-sugars, metabolic engineering, ecsherichia, oligosaccharides
Disciplines:Microbiology, Laboratory medicine, Transport phenomena, Systems biology, Chemical product design and formulation, Catalysis and reacting systems engineering, Separation and membrane technologies, General chemical and biochemical engineering, Other (bio)chemical engineering, Process engineering, Industrial microbiology, Biomaterials engineering, Other (bio)medical engineering, Soil sciences, challenges and pollution, Biological system engineering, Medical biochemistry and metabolism, Biomechanical engineering, Industrial biotechnology, Biocatalysis and enzyme technology, Industrial biotechnology not elsewhere classified, Agriculture, land and farm management, Fermentation, Other biotechnology, bio-engineering and biosystem engineering, Industrial molecular engineering of nucleic acids and proteins, Bioprocessing, bioproduction and bioproducts, Environmental engineering and biotechnology, Biochemistry and metabolism