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MEMCLIP: A comprehensive chemical-biology approach to understand the bioactivity of Pseudomonas cyclic lipopeptides on eukaryotic membranes (MemCLiP)
The activity of cyclic lipopeptides, produced by Pseudomonas bacteria and chemically synthesized analogues will be tested in a standardized way on human (healthy and cancer) cells, plant cell suspensions and fungal cells. Using a combination of biological and (physico-)chemical methods we will test the hypothesis that in all these eukaryotic cells, these lipopeptides act on lipids in the cell membranes.
Date:1 Jan 2019 → 31 Dec 2022
Keywords:solid phase synthesis, innate immunity in plants, structure analysis, anti tumor cell activity, plant cell suspension cultures, fluorescent labeling and tracking, bioactivity and control, Lipopeptides
Disciplines:Bio-organic chemistry, Analytical biochemistry, Lipidomics, Structural analysis, Regulation of metabolism, Lipids