< Back to previous page

Project

Medical risks and developmental deficit 4 years after pediatric critical illness: role of exposure to plastic softeners released from indwelling medical devices (MeDIPlasticS).

The proposed translational research is positioned late in the path from discovery to application, as it will build further on previous mechanistic and epidemiological research. The study rationale builds on evidence from epidemiological studies of much lower exposure to environmental toxicants, on our previous research documenting the legacy of pediatric critical illness and on (unpublished) proof-of-concept studies performed by our group. In a pilot study, concentrations of phthalate (DEHP) metabolites were quantified in plasma collected during PICU stay from children matched for age, type and severity of illness, who were also physically examined and tested for neurocognitive development at 4 year follow-up.
Date:1 Dec 2015 →  30 Nov 2019
Keywords:TOXICOLOGY, PEDIATRICS
Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Project type:Collaboration project