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Project
Looking back into the future: ancestral reconstruction as a strategy for enzyme engineering
Recent studies have shown that present-day enzymes often do not display enough plasticity to allow significant engineering of their substrate preference. Therefore, one of their progenitors will be used here as starting point for the creation of new specificities. Such an ancestral sequence should behave like a pluripotent stem cell that is able to adopt a variety of specialized functions.
Date:1 Oct 2013 → 30 Sep 2017
Keywords:ancestral reconstruction, enzyme engineering, biocatalysis
Disciplines:Environmental engineering and biotechnology, Other (bio)chemical engineering, Process engineering, Medical biochemistry and metabolism, Systems biology, Catalysis and reacting systems engineering, Biological system engineering, Chemical product design and formulation, Biochemistry and metabolism, General chemical and biochemical engineering, Transport phenomena, Biomechanical engineering, Industrial biotechnology, Separation and membrane technologies, Biomaterials engineering, Other (bio)medical engineering, Other biotechnology, bio-engineering and biosystem engineering, Biomaterials, Proteins