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Link between hypoxia and progenitor cells in liver carcinogenesis. (3G033313)

Primary liver cell cancer (hepatocellular carcinoma and cholangiocarcinoma) evolve from a liver progenitor cell. Depending on different pathways (eg Notch pathway) and in the presence or absence of oxygen, these cells can dedifferentiate towards a tumor with hepatocytic or cholangiocytic aspects. These pathways shall be studied in this project.

Date:1 Jan 2013  →  31 Dec 2018
Keywords:hepatocellular carcinoma, progenitor cell, Notch pathway, cholangiocellular carcinoma, hypoxia
Disciplines:Other paramedical sciences, Social medical sciences, Gastro-enterology and hepatology, Laboratory medicine, Regenerative medicine, Other medical and health sciences, Palliative care and end-of-life care, Other translational sciences, Other health sciences, Other clinical sciences, Hepatology, Other basic sciences, Nursing