Light sheet microscopy.

In this project, we will establish and benchmark a whole-brain imaging approach to monitor spreading of neurodegenerative protein aggregates; in other words, we wish to establish 4D reference maps of neurodegenerative pathologies. To this end, we will combine state-of-the-art tissue clearing strategies with advanced light microscopy and image informatics.

Keywords:ALZHEIMER'S DISEASE, MICROSCOPICAL TECHNIQUES, 3D MICROSCOPY

Disciplines:Multimedia processing, Biological system engineering, Signal processing, Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing