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Project

Leucocyte plasma rich fibrin (L-PRF) based promotion of wound healing and tissue regeneration, action profile, underlying mechanisms and clinical implications

Leucocyte plasma rich fibrin (L-PRF) is one of the four families of platelets concentrates used in the surgical field and has been used in oral and maxillofacial wounds where it can modulate hard and soft tissue healing procedure while some studies report on pain –inhibitory and anti-inflammatory properties as well. The mechanisms of action are unclear, and the relative role of their different components have not been fully elucidated. The overall objective is to compare the concentrations and kinetics of wound healing regulators in periodontal soft tissue surgeries with and without local application of LPRF. Ultimately we aim to assess in vitro the differentiation effects of LPRF preparations and its released components on periodontal and gingival fibroblasts, alveolar bone osteoblasts, gingival keratinocytes, endothelial cells and mesenchymal stem cells including gingival and  PDL stem cells.

Date:26 Jun 2018 →  30 Jun 2022
Keywords:wound healing, leucocyte plasma rich fibrin, oral surgery
Disciplines:Dentistry
Project type:PhD project