IRIS: Pathogenesis, clinical and public health aspects.

The pathogenesis, the clinical manifestations and the public health aspects of the Immune reconstitution inflammatoy syndrome(WS) will be studied. In Uganda and Ethiopia we will study how frequent a smear negative pulmonary TB patient with IRIS canbecome smear positive, and what the effect is of lRIS on the health service and the treatment adherence of the patient. Using blood samples obtained during a cohort study in Uganda, we will study whether VitD deficient; and the M. tuberculosis (TB) genotype/"antigen load" plays a role in the pathogenesis of TB-IRIS.

Keywords:INFECTIONS, PATHOGENESIS

Disciplines:Immunology, Tropical medicine, Microbiology, Public health care, Public health sciences, Public health services