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Project
The involvement of neuroinflammation and oxidative stress on alpha-synuclein aggregation and intercellular pathology spread in Parkinson's disease. (FWOTM592)
This project aims to validate neuroprotective compounds that are capable of preventing a-syn aggregation in vivo, by interference of inflammation and the NADPH oxidase related oxidative stress. Furthermore, we will investigate whether these mechanisms are involved in the spread of a-syn pathology. Two questions will be examined:
1) What is the relationship between oxidative stress, inflammation, and a-syn aggregation?
2) Can modulation of inflammation and oxidative stress prevent the spread of PD pathology? Is this effect also obtained by inhibiting the cell-to-cell transmission of a-syn oligomers?
1) What is the relationship between oxidative stress, inflammation, and a-syn aggregation?
2) Can modulation of inflammation and oxidative stress prevent the spread of PD pathology? Is this effect also obtained by inhibiting the cell-to-cell transmission of a-syn oligomers?
Date:1 Oct 2011 → 30 Sep 2015
Keywords:Aminoacids, Parkinsons Disease, Neuro-Transmitters, Neuropharmacology, clinical pharmacy, Stroke, Receptors, Rat Models, Neurochemistry, Pharmacokinetics, Microdialysis, neuroscience, Drug Research, Bioanalysis, Epilepsy, seamless care, Monoamines, Neurosciences, Liquid Chromatography, pharmaceutical care, Electrochemical Detection
Disciplines:(Bio)chemical engineering, Basic sciences, Health sciences, Pharmaceutical sciences