Investigation of nutritional and/or environmental epigenetic modulators in health and disease.

Short exposure to nutrients, toxines, endocrine disruptors, hormones, famine or stress, can have longlasting consequences by epigenetic mechanisms (chromatin code, DNA methylation, noncoding RNAs) which affect the interpretation and expression of the genetic DNA blueprint. As such chronic inflammation is epigenetically recorded in the human genome and increase incidence and progression of various diseases, including metabolic disease, autoimmune disease, cancer, neurodegeneration, cardiovascular disease and ageing. This research will explore how diet and environmental factors interfere with epigenetic regulation of immune homeostasis in health and disease.

Keywords:EPIGENETICS, CELL BIOLOGY, INFLAMMATION, DIET

Disciplines:Biochemistry and metabolism, Genetics, Systems biology, Medical biochemistry and metabolism, Molecular and cell biology