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Introducing mRNA vaccination in chicken: first steps towards a commercial mRNA vaccine against a leading viral infection in chicken (VetCoVac)
In this project we will introduce our self-amplifying mRNA vaccine platform in chicken. To that end we will design and in vitro validate two mRNA vaccines encoding selected antigens of one of the most important pathogens in poultry production. Subsequently, we will formulate the sa-mRNA vaccines with UGent owned lipid nanoparticles and investigate their immunogencity and protection efficacy in a challenge study in chicken.
Date:1 Nov 2022 → Today
Keywords:veterinary vaccines, chicken, mRNA vaccine platform, infectious bronchitis
Disciplines:Veterinary immunology, Veterinary conservation medicine, preventive medicine and hygiene, Biopharmaceutics, Animal health engineering, Chemical product design and formulation not elsewhere classified, Veterinary microbiology