Project
Insight and analytical problem solving in early aging
We live in an aging society, which is accompanied by increasing challenges at the individual, interpersonal, clinical, and societal level. The aging challenge also consists of a rise in the number of older adults suffering from neurological disorders such as stroke. At the same time, our world is also becoming increasingly more complex: it requires efficient and flexible cognitive skills, such as cognitive control. We are continuously bombarded with sensory input. Our cognitive system needs to selectively process relevant input, maintain this input and inhibit irrelevant input, to achieve our goals. However, precisely these cognitive control skills gradually deteriorate with age and can suddenly be affected after stroke. As pharmacological treatments for cognitive decline have limited efficacy, there is an urgent need for non-pharmacological methods to address cognitive impairment. This project specifically aims to unravel the behavioral and neural mechanisms underlying impairment in cognitive control in healthy older adults and stroke survivors. To achieve this, four objectives are formulated. First, we will pinpoint which, when and how cognitive control functions decline in healthy aging. Second, we will expose neural markers and networks of cognitive control decline in healthy aging. Third, we will unravel patterns of stroke-induced cognitive control deficits in stroke survivors. Fourth, we will map the lesion neuroanatomy of post-stroke cognitive control deficits at the network level. To reach these objectives, we propose a multi-method approach, combining cross-sectional, longitudinal and patient studies, behavioral and neuroimaging (EEG and fMRI) techniques and advanced statistical tools (structural equation modelling, network and connectivity analyses). Ultimately, this project will provide the basis for developing new, non-pharmacological intervention programs to delay, decelerate or decrease cognitive control impairment.