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Project
Inhibition of TNFR1 for the treatment of TNF mediated diseases
Anti-TNF therap is succesfully used for the treatment of autoimmune diseases like arthritis, IBD and psoriasis. Some of the complications associated with anti-TNF therapy such as increased risk for infections and new onset autoimmune diseases may be prevented by specific TNFR1 inhibition. This allows functional TNFR2 signaling which may be beneficial for the correct functioning of the immune system.
Date:1 Oct 2013 → 25 Mar 2018
Keywords:Anti-TNF therapy, arthritis, nanobodies, Autoimmune disease, TNF receptors, Multiple Sclerosis, Psoriasis
Disciplines:Biological system engineering, Orthopaedics, Immunology, Industrial biotechnology, Other (bio)medical engineering, Other biotechnology, bio-engineering and biosystem engineering, Biomaterials engineering, Biomechanical engineering, Environmental engineering and biotechnology