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In silico: to genotype HIV drug resistance interpretation and predict HIV evolution with applied and optimalized resistance algorithms and fitness models as bio-informatics tools.In vitro: to study new therapeutic HIV targets, siRNA manipulation and gene therapy, and the induction of anti-HIV cellular immune responses using normal donor and patients' blood cells and viral strains.In vivo: to test the experimental immunological in vitro findings on relevance and/or efficiency in a Trimera mouse HIV model.
Project
Inhibition of human immunodeficiency virus (HIV) replication (HIV Control)
General
The effective inhibition of HIV replication targeting viral escape and resistance under immune and drug pressure.
Specific
In silico: to genotype HIV drug resistance interpretation and predict HIV evolution with applied and optimalized resistance algorithms and fitness models as bio-informatics tools.In vitro: to study new therapeutic HIV targets, siRNA manipulation and gene therapy, and the induction of anti-HIV cellular immune responses using normal donor and patients' blood cells and viral strains.In vivo: to test the experimental immunological in vitro findings on relevance and/or efficiency in a Trimera mouse HIV model.
Date:1 Jan 2007 → 31 Mar 2012
Project type:PhD project