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Hybrid stimuli responsive nanocarriers containing persistent luminescence nanoparticles: Applications in biosensing / bioimaging and theranostics (R-11290)

In recent years, advances in modern medicine have rendered nanomedicine an inevitable option for advanced health care. To this extent, the design and development of drug delivery systems for deadly disease such as cancer is highly sought as it has a large impact on patient survival and improved quality of life. Drug delivery system offers additional in vivo stability by protecting the drug from degradation in the bloodstream, enhancing drug solubility, decreasing toxic side effects and improving the pharmacokinetic and dynamic profiles of drugs. In this regard, stimuli responsive nanocarriers that can allow for controlled release of cargo under the influence of endogenous stimuli is highly interesting. The attempts to deliver cargo are also paralleled by efforts to visualize the targeted tissue. In here, multimodular imaging has evoked lot of interests. Within this project, stimuli responsive nanocarriers sensitive to endogenous triggers and persistent luminescence materials with multimodular imaging properties will be developed. Further, organelle-specific drug loaded hybrid nanocarriers combining luminescence nanoparticles with stimuli responsive polymers will also be developed. Finally the efficacy of the different nanomaterials will be evaluated by studying their biological fate and their performance with respect to imaging, and theranostic properties using a cancer cell line (in vitro).
Date:1 Oct 2021  →  Today
Keywords:nanoparticles and -clusters
Disciplines:Chemistry of clusters, colloids and nanomaterials, Nanobiotechnology, Biosensors, Biomaterials, Biophysics not elsewhere classified
Project type:Collaboration project