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Project

GATA3-mediated epigenetic control of human T cell development (01D08818)

GATA3 is an important transcription factor for the development of T lymphocytes that are important cells of the immune system. Continuing on recently published findings, in this project we wish to investigate how this protein alters epigenetic mechanisms to execute its function. Since GATA3 mutations occur in leukemia, understanding this may have important therapeutic implications.

Date:1 Oct 2018  →  31 Oct 2019
Keywords:T cell development, transcription factors, epigenetics
Disciplines:Laboratory medicine, Immunology, Systems biology, Hematology