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Project

Funtionalised Azabicycloalkanes as conformational restricted Skeletons for structural Analogues of physiological active compounds

The cyanide induced dynamic intramolecular cyclization will be further developed for the synthesis of new azabicyclic skeletons which are important in agrochemistry and pharmaceutical industry. During this study, the attention will be focussed on the synthesis of new 2,4-methanoproline analogues (anti-feedant) as well as tricyclic methanoproline analogues and the syntesis of epibatidine analogues (analgesic activity).

Date:1 Jan 2007 →  31 Oct 2011
Keywords:epibatidine, azabicycloalkanes, methanoproline
Disciplines:Pharmacology, Other chemical sciences, Toxicology and toxinology, Medicinal products, Organic chemistry, Biomarker discovery and evaluation, Agricultural plant production, Pharmacotherapy, Other pharmaceutical sciences, Pharmaceutics, Drug discovery and development, Pharmacognosy and phytochemistry