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From exposome to effect assessment of contaminants in human and animal models (EXPOSOME).
We will develop a pioneering holistic framework based on innovative approaches to explore the human exposome in terms of exposure leading to adverse effects with a focus on endocrine-modulated neurological and metabolic disorders by:i. Identifying and characterizing the exposure sources of relevant chemicals in the context of the xposome framework;ii. developing and applying in silico, in vitro and in vivo human and animal models to investigate the absorption, distribution, metabolism, and excretion processes after exposure to chemicals; iii. setting up relevant clinical/epidemiological exposure-wide association studies to better understand the associations between exposure and neurological and metabolic disorders in longitudinal and (nested) casecontrol cohorts and including birth cohorts to understand transgenerational mechanisms;iv. using targeted and untargeted omics techniques (e.g. metabolomics and transcriptomics) in human and animal biological systems to aid data-driven discovery of causal factors for adverse health effects;v. linking exposure to mixtures by integrating exposome research with the adverse outcome pathway concept, a novel toxicological framework structuring the cascade of biological events from an initial molecular-level perturbation of a biological system to an adverse health outcome.
Date:1 Jan 2020 → Today
Keywords:EXPOSURE ASSESSMENT, ADVERSE OUTCOME PATHWAY, EPIDEMIOLOGY
Disciplines:Environmental health and safety, Epidemiology, Analytical toxicology