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Project

Exploring ultrasound mediated mRNA transfection of lymph nodes and ultrasound-induced tumor ablation as a synergistic anticancer strategy.

This project combines two recent developments in immunotherapy: dendritic cell (DC)-based vaccination and immunogenic cell death (ICD). For this, we will explore high intensity focused ultrasound (HIFU) as a none-invasive means to damage tumor tissue and induce ICD. The immune response will be boosted by immunotherapy using mRNA-loaded microbubbles for ultrasound-triggered delivery of antigen- and adjuvant-mRNA to DCs in vivo.

Date:1 Oct 2015 →  30 Sep 2019
Keywords:immunotherapy, immunogenic cell death, microbubbles, mRNA, HIFU, ultrasound, cancer vaccination, dendritic cell
Disciplines:Oncology, Immunology, Medical biochemistry and metabolism, Morphological sciences, Biochemistry and metabolism