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Project

Exosome biogenesis and the actin cytoskeleton: an exploratory study using bona fide Camelidae nanobodies

Exosomes are small vesicles released by various types of cells and they influence the behavior of a target cell. Unfortunately, the biogenesis, release and uptake of exosomes is poorly understood. Literature and preliminary data show that the actin cytoskeleton is involved in these processes. Using nanobody and shRNA technologies, we will study the contribution of the cytoskeleton in exosome biogenesis.

Date:1 Oct 2015 →  30 Sep 2018
Keywords:shRNA, Exosome biogenesis, nanobody, RNAi, actin binding proteins, single domain antibody, heavy chain antibody, actin cytoskeleton
Disciplines:Biochemistry and metabolism, Medical biochemistry and metabolism, Systems biology