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Evaluation of the role of LRP4 in the regulation of Wnt/Bcatenin dependent Wnt signalling and bone formation.
Therefore, the aim of this study is to further elucidate the role of LRP4 in the Wnt/β-catenin dependent signalling pathway and in the regulation of bone formation. In order to achieve our goal several functional experiments will be performed in vitro and we will evaluate the effect of sclerosteosis causing LRP4 mutations in vivo in mice. This increased knowledge of the role of LRP4 in the regulation of Wnt/β-catenin signalling and bone formation will result in novel opportunities for the development of therapeutics for osteoporosis.
Date:1 Oct 2013 → 30 Sep 2016
Keywords:BONE FORMATION, PROTEINS, OSTEOPOROSIS
Disciplines:Genetics, Systems biology, Molecular and cell biology