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EpiSwitch: Characterization and engineering of the specificity determinants of carbohydrate epimerases to achieve a specificity switch. (EpiSwitch)

Carbohydrate epimerases (CEP) are very interesting enzymes, inverting the configuration of a sugarU+2019s hydroxyl group through a single reaction without prior activation. Our recent CEP classification system revealed a remarkably broad diversity of substrates and products is handled by CEP1 family members. In this project, we aim to identify the specificity determinants of these enzymes by means of mutational analysis.

Date:1 Jan 2017  →  31 Dec 2019
Keywords:enzyme engineering, carbohydrate epimerases, rare sugars
Disciplines:Separation and membrane technologies, General chemical and biochemical engineering, Biomaterials engineering, Chemical product design and formulation, Biochemistry and metabolism, Other (bio)chemical engineering, Medical biochemistry and metabolism, Other biotechnology, bio-engineering and biosystem engineering, Process engineering, Catalysis and reacting systems engineering, Systems biology, Environmental engineering and biotechnology, Biomechanical engineering, Other (bio)medical engineering, Transport phenomena, Industrial biotechnology, Biological system engineering