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Project

Epicranial cortical stimulation: development and evaluation of a novel, minimally invasive, neuromodulation method

Invasive cortical stimulation (ICS) is an neuromodulation method in which electrodes are implanted on the cortex to deliver chronic stimulation. ICS has been used to treat neurological disorders such as neuropathic pain, movement disorders and tinnitus. A significant disadvantage of ICS is its highly invasive nature. Noninvasive neuromodulation methods such as transcranial magnetic stimulation and transcranial current stimulation show great promise in treating some neurological disorders and require no surgery. However, a significant disadvantage is that only short duration stimulation can be delivered, while many disorders require chronic stimulation. This project will develop and evaluate epicranial cortical stimulation - a generic, minimally invasive, neuromodulation method in which a subcutaneous electrode is implanted on the skull to deliver chronic stimulation. This will be achieved by: 1) using computational models to develop and evaluate and finally manufacture epicranial electrode designs, 2) chronic animal experimental models to assess effectiveness and safety. If successful, the method could offer a novel neuromodulation therapy for a range of brain disorders

Date:1 Oct 2019 →  15 Jun 2022
Keywords:Neuromodulation, Cortical stimulation, Tremor
Disciplines:Analogue and digital signal processing, Sensors, biosensors and smart sensors not elsewhere classified, Biomedical instrumentation, Modelling and simulation, Neurosciences not elsewhere classified