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Project
Effect of innate immune signals on leukemia cells for the stimulation of natural killer cells and T helper type 1-polarizing dendritic cells.
In this project, we will investigate the cellular and molecular determinants for optimal activation of human Th 1-polarized DC (DC 1 NK) in a AML tumor model. Our strategy will be to increase the immunogenicity of leukemia cells by loading them with TLR ligands whether or not in combination with transient transfection of immune-stimulating factors in order to trigger DC and NK activation for subsequent cross-priming of Thl/CTL cells.
Date:1 Jan 2008 → 31 Dec 2011
Keywords:LEUKEMIA, IMMUNE SYSTEM
Disciplines:Systems biology, Hematology, Immunology, Laboratory medicine, Morphological sciences, Oncology