Eco-epidemiology and Transmission Dynamics of Rift Valley Fever in Ethiopia with subsequent development of a diagnostic method
Rift Valley fever (RVF) is an emerging zoonotic arthropod-borne viral disease caused by the Rift Valley fever virus (RVFV) that mainly affects domestic livestock (cattle, goats, sheep and camels) as well as humans and represents a serious threat to human health, animal health and livestock production in Africa and in the Arabic Peninsula. The transmission of RVFV is driven by complex eco-climatic factors making the epidemiology of RVF infection difficult to study and to understand. This project is aimed to assess the epidemiology, ecology, and transmission dynamics of RVF in Ethiopia and to develop a diagnostic solution that could aid RVF surveillance in resource-poor settings. Advanced laboratory diagnostic techniques which including the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) gene-editing technology and mathematical, statistical, and spatial modeling techniques will be used to achieve the aims.