Project
Dysbiosis of the human gut ecosystem: characterization and remediation
In recent years, the importance of the microbiota in the
gastrointestinal tract with regards to host health and wellbeing has
been established. Microbiologists have categorized different
microbial community constellations across individuals called
enterotypes. The Bacteroides2 (B2) enterotype has been very
recently associated with low bacterial load, inflammatory disease,
and poor health parameters. In this project, we will determine which
life-style habits and aspects of health status are associated to the
presence and temporal stability of this enterotype. Next, we will study
the functional potential of the community in greater depth, determine
both the existence of B2 subtypes, and explore whether specific B2
subtypes are linked with specific dysbiosis-associated diseases. We
will also test to see if statins, a drug with anti-inflammatory effects,
can modulate the microbiota from B2 to a healthier constellation in
patients suffering from a B2-prevalent disease, ulcerative colitis.
Successful completion of this project can lead to the discovery of
new biomarkers and development of novel intervention strategies for
emerging diseases through the gut microbiota.