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Dynamics and mechanisms of paromomycin and miltefosine drug-resistance in the protozoan parasite Leishmania.

The primary research aims of this project proposal are to unravel the dynamics and mechanisms of PMM and MIL resistance in L. donovani and L. infantum. To this end, our novel in vitro method for induction of drug resistance in amastigotes will enable to exploreseveral aspects of PMM and MIL resistance prior to their routine use in the field. The deliverables of our study will contribute to the implementation of strategies/policies to avoid the appearance of drug resistance and assure the long-term efficacy of MIL and PMM.
Date:1 Jan 2012 →  31 Dec 2015
Disciplines:Microbiology, Systems biology, Laboratory medicine, Veterinary medicine