DOT1L: a key enzyme in joint homeostasis and disease

Osteoarthritis is the most common chronic joint disease with enormous societal costs. We contributed to the discovery that DOT1L, an enzyme that modulates gene expression in the cell nucleus, plays a role in this disease. We aim to further study the role of DOT1L in joint health and disease. We have a particular interest in the way DOT1L regulates Wnt signaling. We will use a translational research approach using state-of-the art technologies in the analysis of patient derived cells and samples combined with innovative mouse models of disease. Our research plan aims to integrate these human and animal model data and to precisely define the DOT1L network and the opportunities it offers to identify new t herapeutic targets.

Keywords:DOT1L

Disciplines:Orthopaedics